Clinical Trials

Consider participating in an active clinical trial near you!

Below is a partial listing of actively recruiting clinical trials. This list focuses on new drugs in development, though there are always many ongoing clinical trials of drugs and devices already on the market. Click here to see the complete list of active clinical trials for dry eye disease at clinicaltrials.gov.

If you are a clinical trial organizer and wish us to add yours to the list below, please contact the Dry Eye Foundation.

SAF312

(Novartis)

Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)

34 study centers in 17 states
Boston area patients, please note BostonSight (Needham) is a study center for this drug. See the BostonSight research page for more information.

A197

(Aramis)

A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease

18 study locations in 9 states

PL9643

(Palatin)

A Phase 3, Multi-Center Study Evaluating PL9643 in Patients With Dry Eye (MELODY-1)

10 sites in 7 states

K-161

(Kowa)

A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dry Eye Disease

Single location - Lakeway, TX

LOU-064

(Novartis)

A Phase 2 Study to Evaluate the Safety and Efficacy of LOU064 in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe)

Many international locations
3 US locations

SURF-200

(Surface Pharmaceuticals)

A Research Study to See How Well an Eye Drop, SURF-200 (0.02% and 0.04% Betamethasone Sodium Phosphate), Works, What Side Effects There Are, and to Compare it With Vehicle (Placebo) in Subjects Diagnosed With Dry Eye Disease and Experiencing An Episodic Flare-Up

28 locations, 13 states

Reproxalap

(Aldeyra)

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

Massachusetts