Dry Eye Subtypes in the Dry Eye Assessment and Management (DREAM) Study: A Latent Profile Analysis (Translational Vision Science & Technology, Nov 2022, Kimberley Yu et al)

Nobody was happy about the DREAM study saying that Omega 3s are not more effective than placebo. But, it did, and it’s been written about extensively. This most recent paper says that they looked into five different dry eye subtypes, and even when they broke the DREAM study data down for each type individually, Omega 3 still wasn’t better than the placebo used in the study.

Conclusions: Five clinically meaningful DED subtypes differed significantly in demographics, symptoms, signs, and systemic disease associations. Omega-3 was not significantly more effective than placebo for any subtype.