Study: Treat dry eye before cataract surgery (again)

I’m motivated to post these studies about cataract surgery because we still have some years to go before it becomes the norm for all cataract patients to have a serious discussion about dryness with their surgeon before surgery.

But… I particularly liked this one because it does NOT involve fancy schmancy stuff. In some circles, the pendulum is swinging pretty far the other way, i.e. many doctors promoting costly cash-pay in-office MGD procedures prior to cataract surgery. This study looked at 120 patients with moderate obstructive MGD. Those who treated it post-operatively with the standard stuff (heat, hygiene, anti-inflammatory) had better MG status after surgery. (Might they have been even better off with one of those costly cash-pays? Dunno.)

Preoperative Management of MGD Alleviates the Aggravation of MGD and Dry Eye Induced by Cataract Surgery: A Prospective, Randomized Clinical Trial. Song P et al, Biomed Res Int. 2019 Apr 11;2019:2737968.

PURPOSE:

To investigate the effect of preoperative treatment and postoperative enhanced anti-inflammatory treatment on alleviating meibomian gland dysfunction (MGD) and dry eye induced by cataract surgery.

DESIGN:

Prospective, randomized clinical trial.

METHODS:

A total of 120 cataract patients with moderate obstructive-MGD were enrolled and randomized with 60:30:30 number of patients in cohorts I, II, and III, respectively: Cohort I: routine postoperative anti-inflammatory treatment; Cohort II: preoperative treatment (warming compress, lid hygiene, and anti-inflammatory treatment) and routine postoperative anti-inflammatory treatment; Cohort III: enhanced postoperative anti-inflammatory treatment.

MAIN OUTCOMES MEASURES:

All participants were examined preoperatively and postoperatively for ocular symptom score (OSS), noninvasive keratographic tear break-up time (NIKBUT), corneal fluorescein staining, Schirmer I test, lid margin, meibum quality and expressibility, and meibomian gland dropout.

RESULTS:

Ocular surface disorders and MGD showed aggravated status at 1 month postoperatively in Cohort I and Cohort III, and the aggravated MGD resolved by 3 months postoperatively. At 1 month postoperatively, Cohort II and Cohort III presented high NIKBUT and low OSS, lid margin, and meibum quality and expressibility (Cohort II vs Cohort I: all P<0.001, respectively; Cohort III vs Cohort I: P=0.011, P=0.024, P=0.046, P=0.045, and P=0.012, respectively). Additionally, Cohort II had better outcomes of lid margin and meibum quality and expressibility than Cohort III at 1 month postoperatively (P=0.031, P=0.026, and P<0.001, respectively). At 3 months postoperatively, Cohort II presented a significantly higher NIKBUT than Cohort I and Cohort III (P<0.001 and P=0.001, respectively).

CONCLUSION:

Preoperative management of MGD is effective and optimal in alleviating obstructive-MGD and dry eye induced by cataract surgery.