night dry eye

Side and stomach sleepers: Faring worse with dry eye... and possibly MGD?

A study by Hank Perry et al (OCLI) was published in Cornea last year showing that dry eye patients who sleep on their side or face down have more dry eye than those who sleep on their backs:

A statistically significant difference was shown with back sleeping compared with left side sleeping using lissamine green staining (analysis of variance, P = 0.005). The Ocular Surface Disease Index score was also found to be elevated in patients who slept on their right or left side (36.4 and 34.1, respectively) as opposed to back sleepers (26.7) with P < 0.05.

That was not nearly so startling as Dr Perry's comments about MGD in an article in this month's EyeWorld, because while the study results specifically stated that there was no statistically significant correlation between sleep position and degree of MGD, Dr Perry and colleagues clearly feel sleep position really does matter to the meibomian glands. For example:

The authors theorized that the problem is a mechanical one. The glands are fairly delicate and they function perfectly when there is nothing compressing them, but if you compress the glands, you have a direct effect on their ability to function, and this in turn leads to increased inflammation in the glands with eventual dropout and increasing severity of meibomian gland dysfunction.

Quite a theory.

This is a topic of keen interest to me. At the Dry Eye Shop we work daily to try to help people find dry eye products - not just gels and ointments but goggles, masks, shields, patches and tapes - that can increase the moisture in their eyes overnight without disrupting their sleep patterns. Their choice of products in many cases is limited by their sleep style - for reasons of safety as much as comfort.

Many people, for example, come to us after a doctor's referral and ask for a mask or goggle that will hold their lids down. This always concerns me, for reasons such as:

 

 

  • If the lids aren't fully closing, what will happen if the mask slips? They might be at risk of a corneal abrasion.

  • If they sleep on their side or stomach, won't it press on their eyes and give them blurry vision in the morning, or worse?

  • If they adjust the mask or goggle too tightly, might it not press dangerously on their eyes, even if they sleep on their back?

  • Et cetera.

So, in my personal recommendations, I have found myself trending more and more towards encouraging people to employ tools that will, without pressing on or even touching their eyelids, block air movement and hold moisture over their eyes.

Examples include:

 

 

 

  • the vaulting shields made by Eye Eco (EyeSeals 4.0, Onyix and Quartz), which, though flexible, will vault the eyes unless pressed down;

  • bubble type bandages like NITEYE and Ortolux, which are stiff enough to hold up to some pressure and keep anything from touching the eyes;

  • post surgical shields such as the LASIK goggle, in extreme cases such as patients with floppy eyelid syndrome, where they must have secure, rigid protection to prevent literally rubbing the eyes (and corneas) on the bedding, or unconsciously rubbing the eyes with their hands during sleep.

In the cases where their doctor insists the lids be held shut, I encourage them to use skin-friendly silicone medical tapes or EyeLocc strips as opposed to masks or Tranquileyes. (To be clear - I think that if you're willing to put in the extra work to customize thickness of the Tranquileyes pads to get a very light pressure, it can work quite well for back sleepers - yet the safety factors remain a concern because they're so patient-specific.)

Then of course there are a host of special cases. Fibromyalgia, multiple chemical sensitivities and innumerable others introduce complicating factors that make the night solutions require ever more creativity. Nevertheless, it can be done!

But to return to the point of the study and the news report in EyeWorld: Is it really possible that physical compression of the meibomian glands from your sleep style could have a direct knock-on effect on your meibomian glands?

I eagerly await solid medical studies to answer this question.

 

 

 

 

 

 

 

 

 

Larger EyeLocc

For those of you with larger orbits who have found this product too small - especially too short top to bottom - I'm very pleased to say that the manufacturer is working with us on a larger version and I received some samples of it last Friday...  It's not much longer but it's a fair amount taller (i.e. from top of lid to cheek) and gets taller sooner rather than a slow taper. I think this one will fit, not everyone, but most of the people who found the original too small. We're still pondering what the best size will be as a one-size-fits-all. We have a few samples of these larger ones in anyone wants to try them.

Refresh PM & Lacri-Lube

Ointments, ointment, ointments...

one of those necessary evils for so many people!

I've been hearing from a lot of people who are concerned at not being able to find Refresh PM, or at least not for an accessible price.

Yes, Refresh PM as well as Refresh Lacri-Lube are on backorder at the manufacturer and have been for some months now, so the wholesalers are running out and many retailers are completely out.

Yes, the Amazon and eBay scalpers are out in force as usual.

Lacri-Lube is easier to find than Refresh PM.

No, so far as I know, neither product is being discontinued. I've learned the hard way not to be too adamant when I say that! Because, you know, that's what I said the first couple of times someone asked me if Unisol 4 was being discontinued, back in mid 2015. ("Of course not!" followed by a quick call to the manufacturer and then.... um... "Oh dear. I can't believe it but...") One never knows for sure, because of course, while we've been talking to Allergan frequently about this, if the product really were being discontinued, from past experience it seems likely that their sales staff might be the last ones to learn.

At any rate, I am ever so cautiously optimistic, emphasis on the

optimistic

, that Refresh PM and LacriLube are merely backordered,

NOT

on their way out.

Meantime, there ARE other ointments available, like

Genteal Ointment

and

Systane Ointment

. The only unique thing about Refresh PM is the proportion of petrolatum to mineral oil (57.3%:42.5%, versus 94%:3% in the Alcon ones). For many people, these details don't matter; for some, they do matter. (You know who you are.)

If you're not able to get Refresh PM at a reasonable price right now, my suggestions would be:

  • Try the Genteal or Systane ones, esp. in combination with some kind of physical barrier at night (plastic wrap? sleep mask? moisture goggle? something anyway)

  • Try Genteal Gel or a similar polymer gel, if other ointments don't agree. Gels dissolve rather than leaving greasy residue.

Rebecca

Managing nighttime symptoms of dry eye

In this Dry Eye Awareness Month series of posts, I've been trying to avoid re-hashing well known or readily available information, focusing instead on the patient-friendly angles that just don't get covered. But in practical things like night protection, I find that the 'information spread' is so large that I don't want to make assumptions... what's old hat to many patients is

completely

unknown to many others who could benefit. So, for night dry eye, I'm going to start by framing it with some key principles.

Fundamentals of night management

  • Eyelid care: For bleph/MGD sufferers, warm compresses and lid hygiene just before bed can help with better nights.

  • Environmental issues: Ceiling fans, heat and A/C are lethal. If they can't be avoided altogether due to factors like climate and partner preferences, then they have to be compensated for aggressively with other forms of physical protection. Finally, in low humidity climates, a humidifier may be necessary, but don't use one unless you're prepared to keep it clean.

  • Lubrication: Do you have a good enough lubricant that is lasting long enough?

  • Physical barrier protection is KEY! Most people with severe symptoms benefit from some type of mask, shield, goggle, patch, or other physical protection at night. This is especially critical if their lids don't fully seal during sleep, but it is definitely not only people with poor lid closure that benefit.

Goop?

Circling back to

an ancient debate

about whether ointments are good or bad. Personally, I don't particularly care about the principle of the thing all that much anymore.

Seems to me that what works, works, and what doesn't, doesn't.

I mean, in theory, I think ointments (i.e. petrolatum and mineral oil in varying proportions, depending which brand of a product with "PM" in its name you choose) are acknowledged by many to be not the greatest idea, in that grease effectively prevents liquid, in this case tears, from reaching the surface it's slathered on, so the eyes don't get the nourishment they need and deserve. But in real life, it's all about what actually works for real people. I have known so many people for so long who always do best with ointment at night. On the other hand, there are those whose eyes do get worse over time when they use ointment nightly, but who may have simply assumed it was disease progression and never questioned whether something they're using might actually be irritating their eyes in some way.

So to me, the bottom line is:

  1. Questioning is always good.

  2. Understand your choices, including the non-lubricant aspects of night dry eye care.

Physical barrier protection

At my DryEyeShop business, a great deal of our phone time is spent in what we call 'night consultations': troubleshooting how best to help someone protect their eyes at night. 

It's really quite a challenge at times to find tools that will accommodate all the different types of constraints that may be in play, and address them well enough for someone to be able to live with it every night. Consider the following variables:

  • Sleep style (back, side, stomach)

  • Material sensitivities (latex, silicone, plastics, foams)

  • Tolerance for things touching the lids while sleeping

  • Skin type and conditions (edema, easily impressible, sensitive)

  • Size and fit issues (large hat size, large orbits, very small head, eyes close together, extremely long lashes, very prominent eyes, very deep set eyes)

  • Eyelid conditions (damage, scarring, missing parts of lids)

  • CPAP usage (full face, nasal pillow, strap configurations)

  • Non-closing eyelids (abrasion risk depending on sleep style? Do we force the lids down or simply vault them and keep the eyes safely sealed in?)

  • Major asymmetries in the facial bone structure

  • Strap constraints (scars, tumors, any scalp irregularities that could pose issues)

  • Medical constraints (can we seal completely or must it be vented?)

  • General safety (ensuring patient can see to prevent falls during the night)

  • Corneal safety (patient rubbing hands in eyes, or eyes on pillow during sleep? How to balance comfort with keeping something securely in place?)

  • Costs (is there a home-made version? A lower-cost alternative? How often does it have to be replaced? Are there parts that have to be replaced periodically?)

  • Maintenance (does it involve too many steps for someone with severe arthritis? Too delicate for someone with Parkinsons?)

  • Et cetera....

WOW. That's actually the first time I have done a rapid-fire stream-of-consciousness list on that topic, and it turned out even longer than I expected it to! It's not exhaustive, either — every single case is different. I could spend weeks writing up all different types of situations we've encountered and tried to find solutions for over the years. I can't address them all in the blog here, but I will tackle a few of the broader issues that come up frequently.

Incidentally, while I don't want to use the blog to push people to my shop, I do want to mention that consulting on these things is always free, and encompasses not just what we sell, but everything we know is available, so feel free to call to brainstorm solutions! We're at 877-693-7939.

What to do when your lids don't close

This is probably the single most common issue that comes up: People whose eyelids don't close need protection to ensure the corneal surface doesn't dry out. Situations range from relatively mild — where one naturally has a small opening between the lids during sleep (not normally a big problem until/unless you also have dry eye!) — to botched blepharoplasties where there might be a slightly wider opening — to wide openings due to facial palsies, damage to eyelid muscles, injuries and so on.

So the first and most basic decision is this:

Do I attempt to force the lids to close?

It has been my experience that if there is any way you can avoid forcing the lids closed, you should — for the very simple reason that forcing the lids down will usually make it harder to sleep, especially in severe cases. There just aren't all that many ways to force the lids down that are comfortable enough to endure all night.

There are lots of exceptions, and one of the most prominent of the exceptions is people who also have recurrent corneal erosions, where immobilizing the eyelids can be very helpful by preventing the sudden eyelid movements that so often precipitate erosions. People with extremely severe aqueous deficient dry eye plus exposure from poor lid closure sometimes also find nothing will protect them adequately short of taping them down.

...Or do I use a sealed moisture chamber?

The idea here is to seal in the eye area to improve humidity around the eye, reduce evaporative tear loss and eliminate any air movement. This may be all that's needed, along with of course an appropriate lubricant.

This is often the most practical route and there are far more choices available, from patches to shields, goggles and masks, whether they have been designed for the purpose or they can be appropriated for the purpose. That's where so many of the issues on my list come into play in the selection and nearly inevitable trial-and-error processes.

CPAP?

Shield/goggle compatibility:

One of my must-do-in-2017-if-at-all-possible projects is to come up with a definitive list of compatibility between all the most commonly used CPAP masks and the commonly used night protection products (Onyix/Quartz, Tranquileyes, EyeSeals, and others). I can often, but not always, tell by looking at pictures online what will fit with what but, depending on the exact strap configuration, in many cases it depends on where exactly the straps rest on someone's face.

Clear, opaque, inside, outside?

There are so often more complications... is it possible given the strap configuration to put the dry eye shield on last, or must it go on first, and if the latter, is it available in a clear version, and if not, how on earth do you manage? Then there are partner complications: you really need something opaque because your partner keeps the light or TV on forever, but your shield will only fit underneath your mask, meaning if you get up in the night you have to completely disentangle yourself from everything. There is so much to all this! Including things like the...

Rare but notable possibility

in stubborn cases: There are documented cases of CPAP-related dry eye problems occurring not from a leaky mask blowing onto the eye surface externally, but rather from a mask on a high setting forcing air up through the

nasolacrimal duct

onto the eye through the puncta.

Stomach sleeper?

Another of the fairly common problems, but hard to solve in a way that someone can get comfortable sleeping. I'm not going to get into lots of detail here (if you're interested, you might want to glance at the little 

article

I wrote about it for the shop) but I'll just touch on the key principles in play:

Any solution used for stomach sleepers with dry eye needs to take account of the following:

  • It must be capable of preventing anything from touching the lids or eyes — either stiff enough or vaulting the eyes high enough or both.

  • It must have a means of securing it in such a way that it can't easily be dislodged.

  • It needs to be comfortable enough to, you know, sleep.

Recurrent corneal erosions?

RCE has been a big hobby horse of mine for years. An awful lot of people with RCE do not get diagnosed properly until it's gone on a long time. Often they have visited several doctors, sometimes even including multiple corneal specialists, before diagnosis. Even when they do get diagnosed, they don't always get treatment specific to the condition. Recurrent Corneal Erosions are a condition that can happen with, or without, dry eye. (What makes it yet more confusing is that erosions can occur when there is severe dry eye, but that's different from RCE as a disorder.)

If you experience episodes of sharp pains in the middle of the night or first thing in the morning in one or both eyes, accompanied by tearing and blurred vision, please talk to your doctor about it. It can't hurt to ask.